Early-Life Cardiorespiratory Fitness and Long-term Risk of Prostate Cancer.

ABSTRACT:

Background

Adolescence is a period of rapid prostatic growth, yet is understudied for susceptibility for future risk of prostate cancer. We examined cardiorespiratory fitness (CRF) in late adolescence in relation to long-term prostate cancer risk.

Methods

A population-based cohort study was conducted of all 699,125 Swedish military conscripts during 1972-1985 (97%-98% of 18-year-old men) in relation to risk of prostate cancer overall, aggressive prostate cancer, and prostate cancer mortality during 1998-2017 (ages 50-65 years). CRF was measured by maximal aerobic workload, and prostate cancer was ascertained using the National Prostate Cancer Register. Muscle strength was examined as a secondary predictor.

Results

In 38.8 million person-years of follow-up, 10,782 (1.5

SUBMITTER: Crump C 

PROVIDER: S-EPMC7642066 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature