Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160.

ABSTRACT: Herpes virus entry mediator (HVEM) regulates positive and negative signals for T cell activation through co-signaling pathways. Dysfunction of the HVEM co-signaling network is associated with multiple pathologies related to autoimmunity, infectious disease, and cancer, making the associated molecules biologically and therapeutically attractive targets. HVEM interacts with three ligands from two different superfamilies using two different binding interfaces. The engagement with ligands CD160 and B- and T-lymphocyte attenuator (BTLA), members of immunoglobulin superfamily, is associated with inhibitory signals, whereas inflammatory responses are regulated through the interaction with LIGHT from the TNF superfamily. We computationally redesigned the HVEM recognition interfaces using a residue

SUBMITTER: Shrestha R 

PROVIDER: S-EPMC7642093 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature