Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4⁺ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis.

ABSTRACT: Cutaneous Leishmaniasis (CL) affects up to one million people every year and treatments are costly and toxic. The regulation of the host immune response is complex and the knowledge of how CD4⁺ T cells are activated and maintained during Leishmania infection is still limited. Current therapies aim to target programmed cell death (PD)-1 and programmed cell death ligand (PD-L)-1 in order to boost T cell activity. However, the role of the PD-1/PD-L1 axis during Leishmania infection is still unclear. In this study, we found that patients with active and post-treatment CL displayed different subsets of CD4⁺PD-1⁺ T cells. Accordingly, L. major-infected mice upregulated PD-1 on activated CD4⁺ T effector cells and PD-L1 on resident m

SUBMITTER: de Freitas E Silva R 

PROVIDER: S-EPMC7642203 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature