Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology.

ABSTRACT: Mitochondria are highly dynamic organelles that can exhibit a wide range of morphologies. Mitochondrial morphology can differ significantly across cell types, reflecting different physiological needs, but can also change rapidly in response to stress or the activation of signaling pathways. Understanding both the cause and consequences of these morphological changes is critical to fully understanding how mitochondrial function contributes to both normal and pathological physiology. However, while robust and quantitative analysis of mitochondrial morphology has become increasingly accessible, there is a need for new tools to generate and analyze large data sets of mitochondrial images in high throughput. The generation of such datasets is critical to fully benefit from rapidly evolving meth

SUBMITTER: Rohani A 

PROVIDER: S-EPMC7642274 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature