Concomitant genetic ablation of L-type Ca_v1.3 (α_1D) and T-type Ca_v3.1 (α_1G) Ca²⁺ channels disrupts heart automaticity.

ABSTRACT: Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the ubiquitously expressed cardiac voltage-gated L-type Ca_v1.2 Ca²⁺ channel isoform, pacemaker cells within the SAN and the atrioventricular node co-express voltage-gated L-type Ca_v1.3 and T-type Ca_v3.1 Ca²⁺ channels (SAN-VGCCs). The role of SAN-VGCCs in automaticity is incompletely understood. We used knockout mice carrying individual genetic ablation of Ca_v1.3 (Ca_v1.3^-/-) or Ca_v3.1 (Ca_v3.1^-/-) channels and double mutant Ca_v1.3^-/-/Ca_v3.1^-/- mice expressing only Ca_v1.2 channels. We show that concomitant loss of SAN-VGCCs prevent

SUBMITTER: Baudot M 

PROVIDER: S-EPMC7642305 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature