Ontology highlight
ABSTRACT:
SUBMITTER: Reading E
PROVIDER: S-EPMC7642415 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201104 1
Resistance-nodulation-division efflux pumps play a key role in inherent and evolved multidrug resistance in bacteria. AcrB, a prototypical member of this protein family, extrudes a wide range of antimicrobial agents out of bacteria. Although high-resolution structures exist for AcrB, its conformational fluctuations and their putative role in function are largely unknown. Here, we determine these structural dynamics in the presence of substrates using hydrogen/deuterium exchange mass spectrometry ...[more]