Validating plasminogen activator inhibitor-1 as a poor prognostic factor in sepsis.

ABSTRACT:

Aim

Our previous report indicated that plasminogen activator inhibitor-1 (PAI-1) levels of ≥83 ng/mL in patients with sepsis tended to be associated with disseminated intravascular coagulation (DIC), suppressed fibrinolysis, multiple organ dysfunction, and mortality. Therefore, the present study aimed to validate whether 83 ng/mL was a useful cut-off value for using PAI-1 levels to predict a poor prognosis in sepsis.

Methods

Patients with sepsis were included in this single-center retrospective study. The patients were classified as having high or low PAI-1 values (<83 ng/mL versus ≥83 ng/mL), and were compared in terms of their pre-DIC state, intensive care unit-free days, continuous renal replacement therapy-free days, ventilator-free days, catecholamine-free days, and 28-

SUBMITTER: Hoshino K 

PROVIDER: S-EPMC7642588 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature