Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis.

ABSTRACT:

Background

Mechanisms that facilitate early infection and inflammation in cystic fibrosis (CF) are unclear. We previously demonstrated that children with CF and parental-reported secondhand smoke exposure (SHSe) have increased susceptibility to bacterial infections. SHSe hinders arachidonic acid (AA) metabolites that mediate immune function in patients without CF, and may influence CF immune dysfunction. We aimed to define SHSe's impact on inflammation mediators and infection in children with CF.

Methods

Seventy-seven children with CF <10 years of age (35 infants <1 year; 42 children 1-10 years) were enrolled and hair nicotine concentrations measured as an objective surrogate of SHSe. AA signalling by serum and macrophage lipidomics, inflammation using blood transcrip

SUBMITTER: Kopp BT 

PROVIDER: S-EPMC7642975 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature