Evaluation of Polygenic Risk Scores for Prediction of Prostate Cancer in Korean Men.

ABSTRACT:

Aims

The purpose of this study is to evaluate an aggregate influence of prostate cancer (PCa) susceptibility variants on the development of PCa in Korean men by using the polygenic risk score (PRS) approach.

Methods

An analysis of 1,001 cases of PCa and 2,641 controls was performed to: (i) identify potential PCa-related risk loci in Koreans and (ii) validate the cumulative association between these loci and PCa using the PRS. Subgroup analyses based on risk stratification were conducted to better characterize the potential correlation to key PCa-related clinical outcomes (e.g., Gleason score, prostate-specific antigen levels). The results were replicated using 514 cases of PCa and 548 controls from an independent cohort.

Results

Genome-wide association analysis from o

SUBMITTER: Oh JJ 

PROVIDER: S-EPMC7643004 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature