Autophagy Takes Center Stage as a Possible Cancer Hallmark.

ABSTRACT: Cancer remains one of the leading causes of death worldwide, despite significant advances in cancer research and improvements in anticancer therapies. One of the major obstacles to curing cancer is the difficulty of achieving the complete annihilation of resistant cancer cells. The resistance of cancer cells may not only be due to intrinsic factors or factors acquired during the evolution of the tumor but may also be caused by chemotherapeutic treatment failure. Conversely, autophagy is a conserved cellular process in which intracellular components, such as damaged organelles, aggregated or misfolded proteins and macromolecules, are degraded or recycled to maintain cellular homeostasis. Importantly, autophagy is an essential mechanism that plays a key role in tumor initiation and progressi

SUBMITTER: Alvarez-Meythaler JG 

PROVIDER: S-EPMC7643020 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature