De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors.

ABSTRACT: Cancer immunotherapies using monoclonal antibodies to block inhibitory checkpoints are showing durable remissions in many types of cancer patients, although the majority of breast cancer patients acquire little benefit. Human melanoma and lung cancer patient studies suggest that immune checkpoint inhibitors are often potent in patients that already have intratumoral T cell infiltrate; although it remains unknown what types of interventions can result in an intratumoral T cell infiltrate in breast cancer. Using non-T cell-inflamed mammary tumors, we assessed what biological processes and downstream inflammation can overcome the barriers to spontaneous T cell priming. Here we show a specific type of combination therapy, consisting of oncolytic virus and chemotherapy, activates necroptosis an

SUBMITTER: Workenhe ST 

PROVIDER: S-EPMC7643076 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature