Coexistence of perseveration and apathy in the TDP-43^Q331K knock-in mouse model of ALS-FTD.

ABSTRACT: Perseveration and apathy are two of the most common behavioural and psychological symptoms of dementia (BPSDs) in amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). Availability of a validated and behaviourally characterised animal model is crucial for translational research into BPSD in the FTD context. We behaviourally evaluated the male TDP-43^Q331K mouse, an ALS-FTD model with a human-equivalent mutation (TDP-43^Q331K) knocked into the endogenous Tardbp gene. We utilised a panel of behavioural tasks delivered using the rodent touchscreen apparatus, including progressive ratio (PR), extinction and visual discrimination/reversal learning (VDR) assays to examine motivation, response inhibition and cognitive flexibility, respectively. Relative to WT litter

SUBMITTER: Kim E 

PROVIDER: S-EPMC7643138 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature