Optimization of membrane dispersion ethanol precipitation process with a set of temperature control improved equipment.

ABSTRACT: Ethanol precipitation is an important separation and purification process in the traditional Chinese medicines (TCMs) industry. In the present study, a membrane dispersion micromixer was applied to achieve good mixing for the ethanol precipitation process of Astragali radix concentrate. New experimental apparatus was set up to rapidly lower the temperature of ethanol solution before mixing with the concentrate. Ethanol precipitation process was optimized according to Quality by design concept. To identify critical material attributes (CMAs), ten batches of Astragali radix were used to prepare concentrates. Calycosin-7-O-β-D-glucoside content, the sucrose content, and the electrical conductivity were found to be CMAs after the correlation analysis and stepwise regression modelling. Definiti

SUBMITTER: Pan J 

PROVIDER: S-EPMC7643161 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature