Catalytic Enantioselective Alkylation of Indoles with trans-4-Methylthio-β-Nitrostyrene.

ABSTRACT: The reaction of the rhodium aqua-complex (S _Rh,R _C)-[Cp*Rh{(R)-Prophos} (OH₂)][SbF₆]₂ [Cp* = C₅Me₅, Prophos = propane-1,2-diyl-bis(diphenylphosphane)] (1) with trans-4-methylthio-β-nitrostyrene (MTNS) gives two linkage isomers (S _Rh,R _C)-[Cp*Rh{(R)-Prophos}(κ¹ O-MTNS)]²⁺ (3-O) and (S _Rh,R _C)-[Cp*Rh{(R)-Prophos}(κ¹ S-MTNS)]²⁺ (3-S) in which the nitrostyrene binds the metal through one of the oxygen atoms of the nitro group or through the sulfur atom, respectively. Both isomers are in equilibrium in dichloromethane solution, t

SUBMITTER: Mendez I 

PROVIDER: S-EPMC7643163 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature