Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons.

ABSTRACT: The chromatin landscape of human brain cells encompasses key information to understanding brain function. Here we use ATAC-seq to profile the chromatin structure in four distinct populations of cells (glutamatergic neurons, GABAergic neurons, oligodendrocytes, and microglia/astrocytes) from three different brain regions (anterior cingulate cortex, dorsolateral prefrontal cortex, and primary visual cortex) in human postmortem brain samples. We find that chromatin accessibility varies greatly by cell type and, more moderately, by brain region, with glutamatergic neurons showing the largest regional variability. Transcription factor footprinting implicates cell-specific transcriptional regulators and infers cell-specific regulation of protein-coding genes, long intergenic noncoding RNAs and m

SUBMITTER: Hauberg ME 

PROVIDER: S-EPMC7643171 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature