Placental growth factor for the prognosis of women with preeclampsia (fullPIERS model extension): context matters.

ABSTRACT:

Background

The fullPIERS risk prediction model was developed to identify which women admitted with confirmed diagnosis of preeclampsia are at highest risk of developing serious maternal complications. The model discriminates well between women who develop (vs. those who do not) adverse maternal outcomes. It has been externally validated in several populations. We assessed whether placental growth factor (PlGF), a biomarker associated with preeclampsia risk, adds incremental value to the fullPIERS model.

Methods

Using a cohort of women admitted into tertiary hospitals in well-resourced settings (the USA and Canada), between May 2010 to February 2012, we evaluated the incremental value of PlGF added to fullPIERS for prediction of adverse maternal outcomes within 48 h after adm

SUBMITTER: Ukah UV 

PROVIDER: S-EPMC7643272 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature