Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer's disease mouse model.

ABSTRACT: Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid-beta (Aβ) on the vascular wall, is a major pathology of Alzheimer's disease (AD) and has been thought to be caused by the failure of Aβ clearance. Although two types of perivascular clearance mechanisms, intramural periarterial drainage (IPAD) and the perivascular cerebrospinal fluid (CSF) influx, have been identified, the exact contribution of CAA on perivascular clearance is still not well understood. In this study, we investigated the effect of CAA on the structure and function of perivascular clearance systems in the APP/PS1 transgenic mouse model. To investigate the pathological changes accompanied by CAA progression, the key elements of perivascular clearance such as the perivascular basement membrane, vascular

SUBMITTER: Kim SH 

PROVIDER: S-EPMC7643327 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature