HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 Allele and Haplotype Frequencies of 28,927 Saudi Stem Cell Donors Typed by Next-Generation Sequencing.

ABSTRACT: Human leukocyte antigen (HLA) allele and haplotype frequency distribution varies widely between different ethnicities and geographical areas. Matching for HLA alleles is essential for successful related and unrelated stem cell transplantation. Among the Saudi population, data on HLA alleles and haplotypes are limited. A cross-sectional study was performed on 28,927 bone marrow donors. The most frequent HLA alleles were HLA-A^*02:01:01G (20.2%), A^*24:02:01G (7.5%); B^*51:01:01G (19.0%), B^*50:01:01G (12.3%); C^*06:02:01G (16.7%), C^*07:02:01G (12.2%); DRB1^*07:01:01 (15.7%), DRB1^*03:01:01G (13.3%); DQB1^*02:01:01G (29.9%), DQB1^*03:02:01G (13.2%); and DPB1^*04:01:01G (35.2%), DPB1

SUBMITTER: Jawdat D 

PROVIDER: S-EPMC7643328 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature