Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder.

ABSTRACT: Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates in depressed patients who attempted suicide. Then we compared them with depressed patients without a suicidal history and age- and sex-matched healthy controls (HCs; i.e., 47 suicide attempters with depression, 47 non-suicide attempters with depression, and 109 HCs). Significant volumetric differenc

SUBMITTER: Kang W 

PROVIDER: S-EPMC7643352 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature