Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood.

ABSTRACT: Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first

SUBMITTER: Mareckova K 

PROVIDER: S-EPMC7643354 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature