ISSEC: inferring contacts among protein secondary structure elements using deep object detection.

ABSTRACT:

Background

The formation of contacts among protein secondary structure elements (SSEs) is an important step in protein folding as it determines topology of protein tertiary structure; hence, inferring inter-SSE contacts is crucial to protein structure prediction. One of the existing strategies infers inter-SSE contacts directly from the predicted possibilities of inter-residue contacts without any preprocessing, and thus suffers from the excessive noises existing in the predicted inter-residue contacts. Another strategy defines SSEs based on protein secondary structure prediction first, and then judges whether each candidate SSE pair could form contact or not. However, it is difficult to accurately determine boundary of SSEs due to the errors in secondary structure prediction. The

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7643357 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature