Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes.

ABSTRACT:

Background

Neutralising antibodies to sclerostin (Scl-Ab) have shown significant potential to induce bone formation and decrease bone resorption, increase strength and substantially reduce fracture risk in animal studies and clinical trials. Mechanical loading negatively regulates sclerostin expression, and sclerostin has been shown to induce RANKL synthesis in osteocytes. However, how Scl-Ab governs osteocyte regulation of osteoclast differentiation and function is not fully understood. We have recently discovered that osteoblasts and osteocytes alter osteoclastogenic signalling (RANKL/OPG) during estrogen-deficiency, and that osteoblast-induced osteoclastogenesis and resorption are exacerbated. However, it is not known whether estrogen deficient osteocytes exacerbate osteoclastog

SUBMITTER: Allison H 

PROVIDER: S-EPMC7643443 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature