Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development.

ABSTRACT:

Aims

Brown fat activation accelerates the uptake of cholesterol-enriched remnants by the liver and thereby lowers plasma cholesterol, consequently protecting against atherosclerosis development. Hepatic cholesterol is then converted into bile acids (BAs) that are secreted into the intestine and largely maintained within the enterohepatic circulation. We now aimed to evaluate the effects of prolonged brown fat activation combined with inhibition of intestinal BA reabsorption on plasma cholesterol metabolism and atherosclerosis development.

Methods and results

APOE*3-Leiden.CETP mice with humanized lipoprotein metabolism were treated for 9 weeks with the selective β3-adrenergic receptor (AR) agonist CL316,243 to substantially activate brown fat. Prolonged β3-AR agonism reduced

SUBMITTER: Zhou E 

PROVIDER: S-EPMC7643538 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature