Regional microglial activation in the substantia nigra is linked with fatigue in MS.

ABSTRACT: The goal of our study is to assess the role of microglial activation in MS-associated fatigue (MSAF) using [F-18]PBR06-PET. Fatigue severity was measured using the Modified Fatigue Impact Scale (MFIS) in 12 subjects with MS (7 relapsing-remitting and 5 secondary progressive) and 10 healthy control participants who underwent [F-18]PBR06-PET. The MFIS provides a total fatigue score as well as physical, cognitive, and psychosocial fatigue subscale scores. Standardized Uptake Value (SUV) 60-90 minute frame PET maps were coregistered to 3T MRI. Voxel-by-voxel analysis using Statistical Parametric Mapping and atlas-based regional analyses were performed. SUV ratios (SUVRs) were global brain normalized. Peak voxel-based level of significance for correlation between total fatigue score and PET upt

SUBMITTER: Singhal T 

PROVIDER: S-EPMC7643614 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature