Genetic variation associated with childhood and adult stature and risk of MYCN-amplified neuroblastoma.

ABSTRACT:

Background

Neuroblastoma is the most common pediatric solid tumor. MYCN-amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood. Genetic determinants of stature increase risk of several adult and childhood cancers, but have not been studied in neuroblastoma despite elevated neuroblastoma incidence in children with congenital overgrowth syndromes.

Methods

We investigated the association between genetic determinants of height and neuroblastoma risk in 1538 neuroblastoma cases, stratified by MYCN-amplification status, and compared to 3390 European-ancestry controls using polygenic scores for birth length (five variants), childhood height (six variants), and adult height (413 variants). We further examin

SUBMITTER: Semmes EC 

PROVIDER: S-EPMC7643638 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature