The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide and tends to be detected at an advanced stage. More effective biomarkers for HCC screening and prognosis assessment are needed and the mechanisms of HCC require further exploration. The role of MAOA in HCC has not been intensively investigated.

Methods

In-house tissue microarrays, genechips, and RNAsequencing datasets were integrated to explore the expression status and the clinical value of MAOA in HCC. Immunohistochemical staining was utilized to determine MAOA protein expression. Intersection genes of MAOA related co-expressed genes and differentially expressed genes were obtained to perform functional enrichment analyses. In vivo experiment was conducted to study the impact of trad

SUBMITTER: Pang YY 

PROVIDER: S-EPMC7643659 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature