Second primary breast cancer after unilateral mastectomy alone or with contralateral prophylactic mastectomy.

ABSTRACT:

Background

An increasing number of patients undergo contralateral prophylactic mastectomy (CPM) for unilateral breast cancer. However, the benefit of CPM has not been quantified in the setting of contemporary breast cancer therapy.

Methods

We performed an analysis of 180 068 patients in the Surveillance, Epidemiology, and End Results (SEER) database, diagnosed with unilateral ductal breast carcinoma between 1998 and 2013 and treated with unilateral mastectomy (UM) or CPM. UM was performed in 146 213 patients (81.2%); CPM was performed in 33 855 patients (19.8%). Primary outcome of interest was cumulative incidence of a second primary breast cancer in the ipsilateral or contralateral breast greater than 3 months after initial diagnosis. Cumulative incidence analysis was based

SUBMITTER: Agarwal S 

PROVIDER: S-EPMC7643660 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature