Development of an IFNγ response-related signature for predicting the survival of cutaneous melanoma.

ABSTRACT:

Background

The tumor microenvironment (TME) plays a critical role in tumorigenesis, development, and therapeutic efficacy. Major advances have been achieved in the treatment of various cancers through immunotherapy. Nevertheless, only a minority of patients have positive responses to immunotherapy, which is partly due to conditions of the immunosuppressive microenvironment. Therefore, it is essential to identify prognostic biomarkers that reflect heterogeneous landscapes of the TME.

Methods and materials

Based upon the ESTIMATE algorithm, we evaluated the infiltrating levels of immune and stromal components derived from patients afflicted by various types of cancer from The Cancer Genome Atlas database (TCGA). According to respective patient immune and stromal scores, we cat

SUBMITTER: Hu B 

PROVIDER: S-EPMC7643661 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature