Differences in proximal tubular solute clearance across common etiologies of chronic kidney disease.

ABSTRACT:

Background

Laboratory measures of glomerular function such as the glomerular filtration rate (GFR) contribute toward clinical evaluation of chronic kidney disease (CKD). However, diverse CKD etiologies have distinct pathological mechanisms that may differentially impact the kidney tubules. Little is known regarding how tubular function changes with varying kidney disease types.

Methods

We used targeted mass spectrometry to quantify paired serum and urine concentration of 11 solutes of proximal tubular secretion in 223 patients from an outpatient CKD cohort. We reviewed clinic notes to ascertain the primary CKD diagnosis and categorized these as vascular, diabetic, glomerular or tubulointerstitial. We used one-way analysis of variance to compare secretory solute clearance acr

SUBMITTER: Wang K 

PROVIDER: S-EPMC7643672 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature