Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease.

ABSTRACT: The σ-2 receptor (S2R) complex has been implicated in CNS disorders ranging from anxiety and depression to neurodegenerative disorders such as Alzheimer's disease (AD). The proteins comprising the S2R complex impact processes including autophagy, cholesterol synthesis, progesterone signaling, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface. While there has been much progress in understanding the role of S2R in cellular processes and its potential therapeutic value, a great deal remains unknown. The International Symposium on Sigma-2 Receptors is held in conjunction with the annual Society for Neuroscience (SfN) conference to promote collaboration and advance the field of S2R research. This review summarizes updates presented at the Fourth Internatio

SUBMITTER: Izzo NJ 

PROVIDER: S-EPMC7643771 | biostudies-literature | 2020 Nov/Dec

REPOSITORIES: biostudies-literature