Dissemination and Stability of the bla_NDM-5-Carrying IncX3-Type Plasmid among Multiclonal Klebsiella pneumoniae Isolates.

ABSTRACT: NDM-5 carbapenemase was mainly identified in Escherichia coli, while the rapid transmission of bla_NDM-5 among Enterobacteriaceae has raised serious public attention. This study identified 14 NDM-5-producing Klebsiella pneumoniae isolates from 107 carbapenem-resistant K. pneumoniae isolates, recovered from blood, urine, and normally sterile body fluids of pediatric patients from January 2016 to December 2018. All NDM-5-producing isolates were highly resistant to β-lactams, while tigecycline and polymyxin B exhibited excellent antimicrobial activity. These 14 strains belonged to 9 different sequence types (STs) and displayed various pulsed-field gel electrophoresis (PFGE) patterns, suggesting that they were not clonally related. S1-PFGE followed

SUBMITTER: Zhu W 

PROVIDER: S-EPMC7643832 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature