High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer.

ABSTRACT:

Background

Antiangiogenic therapy, although part of standard treatment in ovarian cancer, has variable efficacy. Furthermore, little is known about the prognostic biomarkers and factors influencing angiogenesis in cancer tissue. We evaluated the expression of angiopoietin-2 and two endothelial tyrosine kinase receptors, Tie-1 and Tie-2, and assessed their value in the prediction of survival in patients with malignant epithelial ovarian cancer. We also compared the expression of these factors between primary high grade serous tumors and their distant metastasis.

Materials and methods

We evaluated 86 women with primary epithelial ovarian cancer. Matched distal omental metastasis were investigated in 18.6% cases (N = 16). The expression levels of angiogenic factors were evaluat

SUBMITTER: Sopo M 

PROVIDER: S-EPMC7644024 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature