Efficacy and safety of short-term therapy with indigo naturalis for ulcerative colitis: An investigator-initiated multicenter double-blind clinical trial.

ABSTRACT:

Introduction

Indigo naturalis (IN) is a blue pigment extracted from Assam indigo and other plants and has been confirmed to be highly effective for ulcerative colitis (UC) treatment in several clinical studies.

Objective

We conducted a multicenter double-blind study to confirm the efficacy and safety of short-term IN administration.

Methods

A multicenter, randomized controlled trial was conducted between December 2015 and October 2018 in our facilities. Forty-six patients with mild to moderate active UC (Lichtiger index: 5-10) were randomly assigned to the IN group or the placebo group and received 5 capsules (500 mg) twice a day for 2 weeks. We investigated the efficacy according to blood tests and the Lichtiger index before and after administration, and we also exam

SUBMITTER: Uchiyama K 

PROVIDER: S-EPMC7644062 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature