Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity.

ABSTRACT: During malignant transformation and cancer progression, tumor cells face both intrinsic and extrinsic stress, endoplasmic reticulum (ER) stress in particular. To survive and proliferate, tumor cells use multiple stress response pathways to mitigate ER stress, promoting disease aggression and treatment resistance. Among the stress response pathways is ER-associated degradation (ERAD), which consists of multiple components and steps working together to ensure protein quality and quantity. In addition to its established role in stress responses and tumor cell survival, ERAD has recently been shown to regulate tumor immunity. Here we summarize current knowledge on how ERAD promotes protein degradation, regulates immune cell development and function, participates in antigen presentation, exerts

SUBMITTER: Qin X 

PROVIDER: S-EPMC7644137 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature