RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development.

ABSTRACT: The characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral region of the developing and adult mouse prostate, and distinct from the previously identified NKX3.1⁺ luminal castration-resistant cells. Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX1⁺ PLCs are unaffected by androgen deprivation, and do not contribute to the regeneration of the distal luminal compartments. Furthermore, we demonstrate that a transcriptionally similar RUNX1⁺ population emerges at the onset of embryonic prostate specificat

SUBMITTER: Mevel R 

PROVIDER: S-EPMC7644213 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature