The neurophysiology and seizure outcomes of late onset unexplained epilepsy.

ABSTRACT:

Objective

To investigate neurophysiologic and neuroimaging characteristics of patients with late onset unexplained epilepsy (LOUE).

Methods

We performed a retrospective chart review of elderly patients with ICD9 diagnosis codes consistent with epilepsy/seizures. Inclusion criteria included unprovoked seizures, and absence of cortical lesions on magnetic resonance imaging (MRI). Electroencephalograms (EEGs) findings were also analyzed. MRI images were scored for degree of white matter hyperintensities (Fazekas Scale) and mesial temporal atrophy (MTA). Vascular risk factors, and Framingham Heart Study general cardiovascular disease (FHS-CVD) risk scores were compared to controls from the Harvard Aging Brain study (HABS).

Results

We identified 224 LOUE patients and 8% we

SUBMITTER: Sarkis RA 

PROVIDER: S-EPMC7644268 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature