Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture.

ABSTRACT: Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of oxidized phospholipids, leading to membrane damage and cell lysis^1,2. Although other types of necrotic death such as pyroptosis and necroptosis are mediated by active mechanisms of execution^3-6, ferroptosis is thought to result from the accumulation of unrepaired cell damage¹. Previous studies have suggested that ferroptosis has the ability to spread through cell populations in a wave-like manner, resulting in a distinct spatiotemporal pattern of cell death^7,8. Here we investigate the mechanism of ferroptosis execution and discover that ferroptotic cell rupture is mediated by plasma membrane pores, similarly to cell lysis in pyroptosis and necroptosis

SUBMITTER: Riegman M 

PROVIDER: S-EPMC7644276 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature