DNA methylation and adiposity phenotypes: an epigenome-wide association study among adults in the Strong Heart Study.

ABSTRACT:

Background

Elevated adiposity is often posited by medical and public health researchers to be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These health challenges are now thought to be reflected in epigenetic modifications to DNA molecules, such as DNA methylation, which can alter gene expression.

Methods

Here we report the results of three Epigenome Wide Association Studies (EWAS) in which we assessed the differential methylation of DNA (obtained from peripheral blood) associated with three adiposity phenotypes (BMI, waist circumference, and impedance-measured percent body fat) among American Indian adult participants in the Strong Heart Study.

Results

We found differential methylation at 8264 CpG sites associated with at least

SUBMITTER: Crocker KC 

PROVIDER: S-EPMC7644297 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature