Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R^-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects.

ABSTRACT: Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) is the major constituent of Nigella sativa, commonly known as black seed or black cumin, and is globally used in folk (herbal) medicine for treating and preventing a number of diseases and conditions. Several studies have shown that TQ can protect against cardiac damage. This study is aimed at investigating the possible protective effects of TQ on hyperlipidemia-induced cardiac damage in low-density lipoprotein receptor-deficient (LDL-R^-/-) mice. Eight-week-old male LDL-R^-/- mice were randomly divided into normal diet (ND)

SUBMITTER: Pei ZW 

PROVIDER: S-EPMC7644313 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature