Histological Peripheral Margins and Recurrence of Melanoma In Situ Treated with Wide Local Excision.

ABSTRACT:

Background

The incidence of melanoma in situ (MIS) is increasing faster compared to invasive melanoma. Despite varying international practice, a minimum of 5 mm surgical excision margin is currently recommended in the UK. There is no clear guidance on the minimum histological peripheral clearance margins.

Aim

This study compares the histological peripheral clearance margins of MIS using wide local excision (WLE) to the rate of recurrence and progression to invasive disease.

Methods

A retrospective single-center review was performed over a 5-year period. Inclusion criteria consisted of MIS diagnosis, ≥16 years of age, and treatment with WLE with curative intent. Those patients with a recurrence of a previous MIS or with a reported focus of invasion/regression were also

SUBMITTER: Moura FS 

PROVIDER: S-EPMC7644340 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature