Aminophylline for improving acute kidney injury in pediatric patients: A systematic review and meta-analysis.

ABSTRACT:

Objectives

Acute kidney injury (AKI) is a major cause of morbidity and mortality. Whether aminophylline administration can prevent or treat AKI among pediatric patients are not clear. This meta-analysis aimed to assess the efficacy and effectiveness of aminophylline for pediatric AKI.

Methods

We carried out a systematic search of six databases: PubMed, EMBASE/Excerpta Medica, Scopus, Cochrane library, and Google Scholar from January 1995 up till May 2019. Summary measures of risk ratios and standard mean difference were calculated using the random effects model.

Results

We identified seven papers containing data on aminophylline use in children with AKI. Meta-analysis of single-arm studies indicated no statistically significant difference in mean rate of serum creatin

SUBMITTER: Alsaadoun S 

PROVIDER: S-EPMC7644458 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature