Inflammation is a target of medical treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia.

ABSTRACT:

Purpose

To review the role of a persistent prostatic inflammatory status (PIS) in the development and progression of benign prostatic hyperplasia (BPH) associated with lower urinary tract symptoms (LUTS) and which medical therapies approved for LUTS/BPH may reduce persistent PIS.

Methods

Literature search in PubMed up to July 2019.

Results

The cause of histologically defined persistent PIS or chronic prostatic inflammation is multifactorial. It is evident in many men with LUTS/BPH, particularly in older men and in men with a large prostate volume or more severe (storage) LUTS. Additionally, persistent PIS is associated with an increased risk of acute urinary retention and symptom worsening. Of medical therapies approved for LUTS/BPH, the current evidence for a reducti

SUBMITTER: De Nunzio C 

PROVIDER: S-EPMC7644532 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature