Comparison of ⁶⁸Ga-DOTA-JR11 PET/CT with dosimetric ¹⁷⁷Lu-satoreotide tetraxetan (¹⁷⁷Lu-DOTA-JR11) SPECT/CT in patients with metastatic neuroendocrine tumors undergoing peptide receptor radionuclide therapy.

ABSTRACT:

Purpose

Paired imaging/therapy with radiolabeled somatostatin receptor (SSTR) antagonists is a novel approach in neuroendocrine tumors (NETs). The aim of this study was to compare tumor uptake of ⁶⁸Ga-DOTA-JR11 and ¹⁷⁷Lu-satoreotide tetraxetan (¹⁷⁷Lu-DOTA-JR11) in patients with NETs.

Methods

As part of a prospective clinical trial, 20 patients with metastatic NETs underwent ⁶⁸Ga-DOTA-JR11 PET/CT and serial imaging with ¹⁷⁷Lu-satoreotide tetraxetan. PET/CT and SPECT/CT parameters for lesion uptake and absorbed dose of ¹⁷⁷Lu-satoreotide tetraxetan in lesions were compared using linear regression analysis and Pearson correlation.

Results

A total of 95 lesions were analyzed on ⁶⁸Ga-DOTA-JR11 PET/

SUBMITTER: Krebs S 

PROVIDER: S-EPMC7644587 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature