Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence.

ABSTRACT: The phenotypic correlation between human intelligence and brain volume (BV) is considerable (r ≈ 0.40), and has been shown to be due to shared genetic factors. To further examine specific genetic factors driving this correlation, we present genomic analyses of the genetic overlap between intelligence and BV using genome-wide association study (GWAS) results. First, we conduct a large BV GWAS meta-analysis (N = 47,316 individuals), followed by functional annotation and gene-mapping. We identify 18 genomic loci (14 not previously associated), implicating 343 genes (270 not previously associated) and 18 biological pathways for BV. Second, we use an existing GWAS for intelligence (N = 269,867 individuals), and estimate the genetic correlation (r_g) between BV and intelligence to be 0

SUBMITTER: Jansen PR 

PROVIDER: S-EPMC7644755 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature