Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer.

ABSTRACT: Ginger (Zingiber officinale) is one of the most widely consumed dietary supplements worldwide. Its anticancer potential has been demonstrated in various studies. However, ginger roots obtained from different geographical locations showed extensive variability in their activities, mainly due to differences in the levels of bioactive compounds. Here we evaluated the effect of these differences on the anticancer activity of ginger by performing efficacy-based fingerprinting. We characterized the fingerprint profiles of 22 ginger samples using liquid chromatography-mass spectroscopy, followed by a principal component analysis (PCA) and pearson correlation analysis. We also evaluated the anti-proliferative effects (IC₅₀) of these samples on triple-negative breast cancer cells using t

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7644756 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature