Synthesis and biological properties of a series of aryl alkyl disulfide derivatives.

ABSTRACT: Disulfide containing compounds are recognized for their wide range of biological properties and are known for their important applications in the pharmaceutical field. In this study, a series of diaryl disulfides with varying alkyl chain length (C₈-C₁₆) was synthesized and assessed for their physicochemical and biological properties. The interactions of compounds with bovine serum albumin (BSA) was investigated in order to study their ability to bind with blood serum protein. An increase in the binding constants (K_a) was observed with increasing chain length C₈-C₁₂, while a decrease in value was obtained with compounds of chain length C₁₄ and C₁₆ showing a cut off effect at C₁₂. The thermodynamic parame

SUBMITTER: Joondan N 

PROVIDER: S-EPMC7644900 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature