Testosterone levels and cause-specific mortality in the older French men without metabolic syndrome.

ABSTRACT:

Objectives

Previous studies have reported controversial findings regarding the association of testosterone with mortality in older men. This heterogeneity might be partially explained by comorbidities and the presence of metabolic syndrome, as well as differential associations according to causes of death.

Methods

We used data from a random subsample of the Three-City study, in which hormone levels were measured in 338 men ≥65 years without metabolic syndrome who were followed-up for 12 years. Vital status was determined for all participants from different sources. We used inverse-probability-weighted Cox regression to estimate the hazard ratios (HRs) of cause-specific mortality and 95% confidence intervals (CIs).

Results

Over the follow-up period, 130 men died (30 fr

SUBMITTER: Laouali N 

PROVIDER: S-EPMC7644941 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature