Dataset Information

Optimizing the Treatment Pattern for De Novo Metastatic Nasopharyngeal Carcinoma Patients: A Large-Scale Retrospective Cohort Study.

ABSTRACT:

Objectives

To investigate the optimal treatment pattern in patients with de novo metastatic nasopharyngeal carcinoma (NPC).

Methods

We assessed 502 consecutive and unselected de novo metastatic NPC patients in Sun Yat-sen University Cancer Center (SYSUCC) from November 2006 to October 2016 in our study. All patients were treated with palliative chemotherapy (PCT) and 308 patients received locoregional radiotherapy (LRRT) subsequently. Our primary study endpoint was overall survival (OS).

Results

The patients treated with LRRT were associated with improved survival on univariate analysis (3-year OS rate 63.7% vs. 31.8%, P < 0.001) and multivariate analysis (HR 0.52, 95%CI 0.40-0.68, P < 0.001). The overall survival benefit of more than 4 PCT cycles was significant in female (HR 0.45, 95% CI 0.24-0.86, P = 0.016) and patients with multiple metastatic sites (HR 0.42, 95% CI 0.26-0.66, P < 0.001). The application of concurrent chemotherapy (CCT) was not associated with better survival among patients receiving LRRT (HR 1.31, 95% CI 0.92-1.86, P = 0.141).

Conclusion

LRRT prolonged survival in de novo metastatic NPC. For patients treated with multiple metastatic sites, more than 4 cycles of PCT is necessary. CCT does not improve survival in de novo metastatic NPC patients.

SUBMITTER: Sun XS

PROVIDER: S-EPMC7645036 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Optimizing the Treatment Pattern for <i>De Novo</i> Metastatic Nasopharyngeal Carcinoma Patients: A Large-Scale Retrospective Cohort Study.

Sun Xue-Song XS Liang Yu-Jing YJ Chen Qiu-Yan QY Guo Shan-Shan SS Liu Li-Ting LT Sun Rui R Luo Dong-Hua DH Tang Lin-Quan LQ Mai Hai-Qiang HQ

Frontiers in oncology 20201023

<h4>Objectives</h4>To investigate the optimal treatment pattern in patients with <i>de novo</i> metastatic nasopharyngeal carcinoma (NPC).<h4>Methods</h4>We assessed 502 consecutive and unselected <i>de novo</i> metastatic NPC patients in Sun Yat-sen University Cancer Center (SYSUCC) from November 2006 to October 2016 in our study. All patients were treated with palliative chemotherapy (PCT) and 308 patients received locoregional radiotherapy (LRRT) subsequently. Our primary study endpoint was o ...[more]

PMID: 33194602

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