Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies.

ABSTRACT: Advances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. At the same time, the clinical successes achieved with minimally invasive and optically-guided surgery and image-guided and ablative radiation strategies have been successfully implemented in clinical care. More effective, localized and safer treatments have fueled strong research interest in radioimmunotherapy, which has shown the potential immunomodulatory effects of ionizing radiation. However, increasingly more observations suggest that immunosuppressive changes, metabolic remodeling, and angiogenic responses i

SUBMITTER: Benavente S 

PROVIDER: S-EPMC7645077 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature