ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans.

ABSTRACT: As part of the ZOOMICS project, we set out to investigate common and diverging metabolic traits in the blood metabolome across various species by taking advantage of recent developments in high-throughput metabolomics. Here we provide the first comparative metabolomics analysis of fresh and stored human (n = 21, 10 males, 11 females), olive baboon (n = 20), and rhesus macaque (n = 20) red blood cells at baseline and upon 42 days of storage under blood bank conditions. The results indicated similarities and differences across species, which ultimately resulted in a differential propensity to undergo morphological alterations and lyse as a function of the duration of refrigerated storage. Focusing on purine oxidation, carboxylic acid, fatty acid, and arginine metabolism

SUBMITTER: Bertolone L 

PROVIDER: S-EPMC7645159 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature